For iontophoresis, which medication is commonly used for inflammation in acute musculoskeletal conditions?

• A. Lidocaine
• B. Saline
• C. Dexamethasone
• D. Acetaminophen

Answer: (C)

Iontophoresis uses a mild electrical current to push a charged drug through the skin so it reaches inflamed tissues directly, providing localized anti-inflammatory effect for acute musculoskeletal injuries. Dexamethasone fits this role well because it is a potent anti-inflammatory corticosteroid that can be delivered as a soluble, ionizable salt (like dexamethasone phosphate) suitable for iontophoresis. This allows the medication to reduce swelling, redness, and pain at the site of inflammation with minimal systemic exposure when used properly.

Lidocaine would mainly numb the area and relieve pain without addressing the underlying inflammation. Saline acts as a vehicle with no anti-inflammatory action. Acetaminophen is a systemic analgesic and not used for local anti-inflammatory effects via iontophoresis. Therefore, dexamethasone is the appropriate choice for treating inflammation in acute musculoskeletal conditions with iontophoresis.